Percutaneous Retrieval of Implanted Leadless Pacemakers Feasibility at 2.5 Years Post-Implantation in an in Vivo Ovine Model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F15%3A%230007167" target="_blank" >RIV/00023884:_____/15:#0007167 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Percutaneous Retrieval of Implanted Leadless Pacemakers Feasibility at 2.5 Years Post-Implantation in an in Vivo Ovine Model

Original language description

Objectives: This in vivo ovine study describes the feasibility and safety of retrieving implanted leadless pacemakers (LPs). Background: Although LPs have been shown to be removable soon after implantation, there are no data on the feasibility of removing chronically implanted LPs. Methods This study was performed in 2 phases. In the mid-term cohort, 10 chronically (5.3 months) implanted animals underwent retrieval, followed by: 1) immediate necropsy in 5; and 2) in the remaining 5, reimplantation of a new LP followed by necropsy at 6 weeks. In the long-term cohort, 8 additional sheep underwent retrieval at 2.3 0.1 years followed by necropsy. Retrieval was performed using either a single or triple loop snare. All 18 LPs (100%) were successfully retrieved. The time from retrieval catheter insertion to retrieval was 2:35 01:11 and 3:04 01:13 minutes in the mid-term and long-term study groups, respectively. Results: There were no significant differences in retrieval times using either snare. Intracardiac echocardiography was used pre- and post-retrieval to confirm the absence of pericardial effusion in all 8 sheep. On necropsy, there was no evidence of pericardial bleeding or perforation. Only minor tissue disruption and hemorrhage was noted at the implant site after retrieval. Histology demonstrated fibrous connective tissue at the contact sites of endocardium and LP can and at the helix. There was no evidence of pulmonary thromboembolism. Conclusions We demonstrate the feasibility and safety of percutaneous, catheter-based retrieval in chronic LP implants of a maximum duration of approximately 2.5 years.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the American College of Cardiology: Clinical Electrophysiology

ISSN

2405-500X

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

563-570

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84951983665