Left Atrial Appendage Closure in Patients With Contraindications to Oral Anticoagulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F16%3A%230006959" target="_blank" >RIV/00023884:_____/16:#0006959 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Left Atrial Appendage Closure in Patients With Contraindications to Oral Anticoagulation

Original language description

The PROTECT AF (Watchman Left Atrial Appendage Closure Technology for Embolic Protection in Patients With Atrial Fibrillation) and PREVAIL (Prospective Randomized Evaluation of the Watchman LAA Closure Device In Patients With Atrial Fibrillation Versus Long-Term Warfarin Therapy) trials revealed that in atrial fibrillation (AF) patients suitable for oral anticoagulation (OAC), mechanical left atrial appendage closure (LAAC) with a catheter-delivered heart implant device (Watchman; Boston Scientific, Marlborough, Massachusetts) is effective for stroke prevention 1 and 2. Importantly, these patients received at least 6 weeks of OAC. Although there is no randomized LAAC trial in OAC-contraindicated patients, there is 1 prospective nonrandomized study of Watchman in these patients (n = 150; CHA2DS2-VASc [Congestive heart failure; Hypertension; Age; Diabetes mellitus; prior Stroke, TIA, or thromboembolism; Vascular disease; Age; Sex category {female}] score = 4.4) (3). In this trial, ASAP (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology), the post-implantation annual ischemic stroke rate was 1.7%, representing 77% fewer strokes than expected for this population. Although promising, the mean follow-up in ASAP was only 1.2 years, so there have been few long-term data regarding LAAC in OAC-contraindicated patients. Herein, we report the 5-year follow-up of ASAP.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the American College of Cardiology

ISSN

0735-1097

e-ISSN

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Volume of the periodical

67

Issue of the periodical within the volume

18

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

2190-2192

UT code for WoS article

000375406100016

EID of the result in the Scopus database

2-s2.0-84966526573