Novel Porcine Model of Acute Severe Cardiogenic Shock Developed by Upper-Body Hypoxia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F16%3A%230007010" target="_blank" >RIV/00023884:_____/16:#0007010 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/16:00305992 RIV/00216208:11110/16:10329184

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel Porcine Model of Acute Severe Cardiogenic Shock Developed by Upper-Body Hypoxia

Original language description

Despite the urgent need for experimental research in the field of acute heart failure and, particularly cardiogenic shock, currently there are only limited options in large animal models enabling research using devices applied to human subjects. The majority of available models are either associated with an unacceptably high rate of acute mortality or are incapable of developing sufficient severity of acute heart failure. The objective of our research was to develop a novel large animal model of acute severe cardiogenic shock. Advanced left ventricular dysfunction was induced by global myocardial hypoxia by perfusing the upper body (including coronary arteries) with deoxygenated venous blood. The model was tested in 12 pigs: cardiogenic shock with signs of tissue hypoxia developed in all animals with no acute mortality. Cardiac output decreased from a mean ( SD) of 6.61 1.14 l/min to 2.75 0.63 l/min, stroke volume from 79.7 9.8 ml to 25.3 7.8 ml and left ventricular ejection fraction from 61.2 4.3 % to 17.7 4.8 % (P 0.001 for all comparisons). In conclusion, the porcine model of acute cardiogenic shock developed in the present study may provide a basis for studying severe left ventricular dysfunction, low cardiac output and hypotension in large animals. The global myocardial hypoxia responsible for the decrease in cardiac contractility was not associated with acute death in this model.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

711-715

UT code for WoS article

000386685600018

EID of the result in the Scopus database

2-s2.0-84997531320