Hypercholesterolemia During Pregnancy is Caused by Increased Endogenous Cholesterol Synthesis: Let’s Use it for Screening of Familial Hypercholesterolemias Too!

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F17%3A00007625" target="_blank" >RIV/00023884:_____/17:00007625 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.6000/1929-5634.2017.06.04.1" target="_blank" >http://dx.doi.org/10.6000/1929-5634.2017.06.04.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.6000/1929-5634.2017.06.04.1" target="_blank" >10.6000/1929-5634.2017.06.04.1</a>

Result language

angličtina

Original language name

Hypercholesterolemia During Pregnancy is Caused by Increased Endogenous Cholesterol Synthesis: Let’s Use it for Screening of Familial Hypercholesterolemias Too!

Original language description

Abstract: Aims: To demonstrate the origin and the diagnostic significance of non-cholesterol sterols (NCSs) in healthy pregnant women with gestational hypercholesterolemia. Patients and Methods: Based on a total of 21,000 clinical biochemistry tests of healthy pregnant women with hypercholesterolemia observed during pregnancy, a group of 84 women with TC (total cholesterol) >7.0 mmol/L was recruited to analyze their NCSs using Gas Chromatography–Mass Spectrometry. The NCSs under examination comprised lathosterol (Lat) and desmosterol (Des) as markers of endogenous cholesterol synthesis, and campesterol (Cam) and sitosterol (Sit) as markers for intestinal absorption. Results: In the total of 21,000 pregnant women, the median values were: TC 6.8 mol/l, LDL-C 4.6 mmol/L, and HDL-C 2.2 mmol/L. In the testing group of 84 women, the average values were: Lat 7.8+/-1.7 μmol/L, Des 4.7+/-0.9 μmol/L, Cam 9.8+/-2.6 μmol/L, and Sit 9.6 +/-3.8 μmol/L. Lat was found to correlate with TC (r = 0.53), LDL-C (r = 0.36), and non-HDL-C (r = 0.35). No such correlations were observed for Sit (r = 0.162) or Cam (r = 0.153). Conclusion: Our findings show that the high incidence of hypercholesterolemia during pregnancy is caused by increased endogenous cholesterol synthesis via lathosterol. The enormous rise of TC levels during pregnancy can be effectively used to detect familial hypercholesterolemia in women. Keywords: Hypercholesterolemia during pregnancy, familial hypercholesterolemia, non-cholesterol sterols, lathosterol, desmosterol, campesterol, sitosterol.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Nutritional Therapeutics

ISSN

1929-5634

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

4

Country of publishing house

CA - CANADA

Number of pages

5

Pages from-to

79-83

UT code for WoS article

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EID of the result in the Scopus database

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