Gamma knife radiosurgery for local recurrence of glioblastoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F18%3A00007840" target="_blank" >RIV/00023884:_____/18:00007840 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gamma knife radiosurgery for local recurrence of glioblastoma

Original language description

OBJECT. Local recurrence of glioblastoma is observed in most patients after standard oncologic treatment (surgery, chemotherapy and radiotherapy). Gamma Knife radiosurgery has been used to treat these recurrence tumors in selected cases and retrospective analysis of treatment was performed. METHODS. Altogether 126 patients were treated for glioblastoma during 1992-2014 in our center. There were 69 (55%) male and 57 (45%) female with median age of 56 years (range 17-80 years). From this group 123 (98%) underwent surgery, 126 (100%) radiotherapy and 116 (92%) chemotherapy before the LGK radiosurgery. Median Karnofsky score before the LGK radiosurgery for patients in this group was 90% (range 50-100), median time from diagnosis of glioblastoma to the LGK radiosurgery was 12 months (range 1- 96 months). Median tumor volume was 3.75 cm3 (range 0.04 – 37.10 cm3). Patients in this study were treated by the LGK radiosurgery performed in single fraction with median minimal tumor dose of 12 Gy (range 10 – 25 Gy) on median 50 % (range 40 – 86 %) isodose line. Two and more LGK radiosurgeries were performed in 19 (15 %) cases. Repeated radiosurgery was performed in 19 (15 %) cases median time 9.6 months (range 2-45 months) from the initial gamma knife surgery. Median prescribed dose in these patients was 12.6 Gy (range 10-15 Gy), median volume 5.8 cm3 (range 0.1-13.7 cm3). RESULTS. Median patients’ survival since glioblastoma diagnosis was 20 months (range 6 – 237 months). Median patients’ survival after the LGK radiosurgery was 7 months (range 1 – 223 months). 1 year survival after the LGK radiosurgery was 27% of patients, 2 years – 8% of patients and more than 3 years – 4% of patients. Tumor regression on MR images was observed in 17% of patients, the median time was 7 months. The median time to tumor progression on MR images after Gamma Knife treatment was 8,5 months. No treatment related radionecrosis with expansive behavior was detected after radiosurgery. CONCLUSION. Presented study showed that Gamma Knife radiosurgery is a safe palliative treatment modality in selected patients with recurrent glioblastoma.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

4

Country of publishing house

SE - SWEDEN

Number of pages

7

Pages from-to

281-287

UT code for WoS article

000453287500002

EID of the result in the Scopus database

2-s2.0-85060123594