Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F19%3A00008380" target="_blank" >RIV/00023884:_____/19:00008380 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10401245

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/31541405" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/31541405</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11060-019-03296-8" target="_blank" >10.1007/s11060-019-03296-8</a>

Result language

angličtina

Original language name

Safety and efficacy of repeat radiosurgery for acromegaly: an International Multi-Institutional Study

Original language description

Purpose Surgical resection is the first line treatment for growth hormone (GH) secreting tumors. Stereotactic radiosurgery (SRS) is recommended for patients who do not achieve endocrine remission after resection. The purpose of this study was to evaluate safety and efficacy of repeat radiosurgery for acromegaly. Methods Three hundred and ninety-eight patients with acromegaly treated with the Gamma Knife radiosurgery (Elekta AB, Stockholm) were identified from the International Gamma Knife Research Foundation database. Among these, 21 patients underwent repeated SRS with sufficient endocrine follow-up and 18 patients had sufficient imaging follow-up. Tumor control was defined as lack of adenoma progression on imaging. Endocrine remission was defined as a normal IGF-1 concentration while off medical therapy. Results Median time from initial SRS to repeat SRS was 5.0 years. The median imaging and endocrine follow-up duration after repeat SRS was 3.4 and 3.8 years, respectively. The median initial marginal dose was 17 Gy, and the median repeat marginal dose was 23 Gy. Of the 18 patients with adequate imaging follow up, 15 (83.3%) patients had tumor control and of 21 patients with endocrine follow-up, 9 (42.9%) patients had endocrine remission at last follow-up visit. Four patients (19.0%) developed new deficits after repeat radiosurgery. Of these, 3 patients had neurologic deficits and 1 patient had endocrine deficit. Conclusions Repeat radiosurgery for persistent acromegaly offers a reasonable benefit to risk profile for this challenging patient cohort. Further studies are needed to identify patients best suited for this type of approach.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuro-Oncology

ISSN

0167-594X

e-ISSN

—

Volume of the periodical

145

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

301-307

UT code for WoS article

000496571900012

EID of the result in the Scopus database

2-s2.0-85074423995