Whole brain apparent diffusion coefficient measurements correlate with survival in glioblastoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F19%3A00008401" target="_blank" >RIV/00023884:_____/19:00008401 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11060-019-03357-y" target="_blank" >https://link.springer.com/article/10.1007%2Fs11060-019-03357-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11060-019-03357-y" target="_blank" >10.1007/s11060-019-03357-y</a>
Alternative languages
Result language
angličtina
Original language name
Whole brain apparent diffusion coefficient measurements correlate with survival in glioblastoma patients
Original language description
Introduction: Glioblastoma (GBM) is the most common malignant primary brain tumor, and methods to improve the early detection of disease progression and evaluate treatment response are highly desirable. We therefore explored changes in whole-brain apparent diffusion coefficient (ADC) values with respect to survival (progression-free [PFS], overall [OS]) in a cohort of GBM patients followed at regular intervals until disease progression. Methods: A total of 43 subjects met inclusion criteria and were analyzed retrospectively. Histogram data were extracted from standardized whole-brain ADC maps including skewness, kurtosis, entropy, median, mode, 15th percentile (p15) and 85th percentile (p85) values, and linear regression slopes (metrics versus time) were fitted. Regression slope directionality (positive/negative) was subjected to univariate Cox regression. The final model was determined by aLASSO on metrics above threshold. Results: Skewness, kurtosis, median, p15 and p85 were all below threshold for both PFS and OS and were analyzed further. Median regression slope directionality best modeled PFS (p = 0.001; HR 3.3; 95% CI 1.6–6.7), while p85 was selected for OS (p = 0.002; HR 0.29; 95% CI 0.13–0.64). Conclusions: Our data show tantalizing potential in the use of whole-brain ADC measurements in the follow up of GBM patients, specifically serial median ADC values which correlated with PFS, and serial p85 values which correlated with OS. Whole-brain ADC measurements are fast and easy to perform, and free of ROI-placement bias.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
<a href="/en/project/NV18-04-00457" target="_blank" >NV18-04-00457: Detection of the dynamic of gadolinium retention in the brain after application of MR contrast agents using alteration of T1 and T2 relaxation times. Prospective study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuro-Oncology
ISSN
0167-594X
e-ISSN
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Volume of the periodical
146
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
157-162
UT code for WoS article
000500262200001
EID of the result in the Scopus database
2-s2.0-85076002149