Clinical course of patients with pantothenate kinase-associated neurodegeneration (PKAN) before and after DBS surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F19%3A00008547" target="_blank" >RIV/00023884:_____/19:00008547 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10400683 RIV/00064165:_____/19:10400683

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00415-019-09499-3" target="_blank" >https://link.springer.com/article/10.1007%2Fs00415-019-09499-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-019-09499-3" target="_blank" >10.1007/s00415-019-09499-3</a>

Result language

angličtina

Original language name

Clinical course of patients with pantothenate kinase-associated neurodegeneration (PKAN) before and after DBS surgery

Original language description

ntroduction Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disorder with a progressive clinical course. In addition to symptomatic therapy, DBS has been increasingly recognized as a potential therapeutic strategy, especially in severe cases. Therefore, we wanted to report our experience regarding benefits of DBS in five PKAN cases in 3-year follow-up study. Methods Five genetically confirmed PKAN patients from Serbia underwent GPi-DBS. To assess clinical outcome, we reviewed medical charts and applied: Schwab and England Activities of Daily Living Scale (S&E), EQ-5D questionnaire for quality of life, Patient Global Impression of Improvement (GPI-I), Functional Independence Measure (FIM), Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Barry Albright Dystonia Scale (BAD). Patients were evaluated in five visits: at the disease onset, 5 years after the onset, before surgery, 6 months and 14-36 months after the surgery. Improvement of 20% was accepted as significant. Results Overall, dystonia significantly improved after GPi-DBS at 6 and 14-36 months postoperatively, when assessed by the BFMDRS and BAD. However, two patients failed to improve considerably. Four patients reported improvement on GPI-I, while one remained unchanged. Three patients reported significant improvement, when assessed with S&E and FIM. EQ-5D showed the most prominent improvement in the domains of mobility and pain/discomfort. Conclusion Three out of our five patients experienced beneficial effects of the GPi-DBS, in up to 36 months follow-up. Two patients who had not reached significant improvement had longer disease duration; therefore, it might be reasonable to recommend GPi-DBS as soon as dystonia became disabling.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurology

ISSN

0340-5354

e-ISSN

—

Volume of the periodical

266

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

2962-2969

UT code for WoS article

000496025500007

EID of the result in the Scopus database

2-s2.0-85072025859