Eye movement abnormalities are associated with brainstem atrophy in Wilson disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F20%3A00008495" target="_blank" >RIV/00023884:_____/20:00008495 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/20:00341261 RIV/00216208:11110/20:10411018 RIV/00064165:_____/20:10411018
Result on the web
<a href="https://link-springer-com.ezproxy.lib.cas.cz/article/10.1007/s10072-019-04225-3" target="_blank" >https://link-springer-com.ezproxy.lib.cas.cz/article/10.1007/s10072-019-04225-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10072-019-04225-3" target="_blank" >10.1007/s10072-019-04225-3</a>
Alternative languages
Result language
angličtina
Original language name
Eye movement abnormalities are associated with brainstem atrophy in Wilson disease
Original language description
Backgrounds This study aims to characterize eye movement abnormalities in Wilson disease and examine their association with the degree of brainstem atrophy. Methods Twenty patients (10 males, mean age 46.8, SD 8.9 years) with genetically confirmed neurological WD on stable anti-copper treatment and 20 age- and sex-matched healthy subjects were examined. Eye movements, including prosaccade and antisaccade tasks, were evaluated using infrared videooculography. MRI was performed using 1.5 T system, and T-2-weighted images were used for the measurement of midbrain and pontine area on mid-sagittal slices. Clinical severity was assessed using the Unified Wilson's Disease Rating Scale (UWDRS). Results Compared to healthy controls, WD patients showed prolonged latencies of horizontal prosaccades and hypometry of both horizontal (p = 0.04) and vertical (p = 0.0046) prosaccades. In the antisaccade task, WD patients showed prolonged latency of both horizontal (p = 0.04) and vertical antisaccades (p = 0.047) and increased error rate of vertical antisaccades (p = 0.04). There is a significant association between midbrain area and horizontal latencies (r = -0.53; p = 0.02) and vertical maximum speed in prosaccades (r = 0.47; p = 0.04). The pons area inversely correlated with horizontal prosaccade and antisaccade latencies (p = 0.007). Conclusions We showed impairments of ocular saccades such as prolonged latencies, hypometry, and increased error rate in antisaccades. The strong association between prolonged latencies of prosaccades and the brainstem atrophy suggests that VOG might serve as a sensitive electrophysiological marker of brainstem dysfunction in WD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkers of progression and treatment response in neurodegenerative disorders</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurological Sciences
ISSN
1590-1874
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
5
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
1097-1103
UT code for WoS article
000505377400010
EID of the result in the Scopus database
2-s2.0-85077243554