Altered sensorimotor fMRI directed connectivity in Parkinson's disease patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F20%3A00008794" target="_blank" >RIV/00023884:_____/20:00008794 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.15053" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.15053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ejn.15053" target="_blank" >10.1111/ejn.15053</a>

Result language

angličtina

Original language name

Altered sensorimotor fMRI directed connectivity in Parkinson's disease patients

Original language description

Dopamine depletion in the axons of Parkinson's disease (PD) patients precedes depletion in cell bodies thus proposing that macroscopic connectivity can be used to understand disease mechanism. A novel multivariate functional connectivity analysis, based on high order coherence among four fMRI BOLD signals was applied on resting‐state fMRI data of controls and PD patients (OFF and ON medication states) and unidirectional multiple‐region pathways in the sensorimotor system were identified. Pathways were classified as “preserved” (unaffected by the disease), “damaged” (not observed in patients) and “corrected” (observed in controls and in PD‐ON state). The majority of all pathways were feedforward, most of them with the pattern “S1→M1→SMA.” Of these pathways, 67% were “damaged,” 28% “preserved,” and 5% “corrected.” Prefrontal cortex (PFC) afferent and efferent pathways that corresponded to goal directed and habitual activities corresponded to recurrent circuits. Eighty‐one percent of habitual afferent had internal cue (i.e., M1→S1→), of them 79% were “damaged” and the rest “preserved.” All goal‐directed afferent had external cue (i.e., S1→M1→) with third “damaged,” third “preserved,” and third “corrected.” Corrected pathways were initiated in the dorsolateral PFC. Reduced connectivity of the SMA and PFC resulted from reduced sensorimotor afferent to these regions. Reduced sensorimotor internal cues to the PFC resulted with reduced habitual processes. Levodopa effects were for pathways that started in region reach with dopamine receptors. This methodology can enrich understudying of PD mechanisms in other (e.g., the default mode network) systems.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Neuroscience

ISSN

1460-9568

e-ISSN

—

Volume of the periodical

53

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1976-1987

UT code for WoS article

000598087600001

EID of the result in the Scopus database

2-s2.0-85097489227