Validation and Update of the Lémann Index to Measure Cumulative Structural Bowel Damage in Crohn’s Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009059" target="_blank" >RIV/00023884:_____/21:00009059 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10432404
Result on the web
<a href="https://doi.org/10.1053/j.gastro.2021.05.049" target="_blank" >https://doi.org/10.1053/j.gastro.2021.05.049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.gastro.2021.05.049" target="_blank" >10.1053/j.gastro.2021.05.049</a>
Alternative languages
Result language
angličtina
Original language name
Validation and Update of the Lémann Index to Measure Cumulative Structural Bowel Damage in Crohn’s Disease
Original language description
Background The Lémann index is a tool measuring cumulative structural bowel damage in Crohn’s disease (CD). We here report its validation and updating. Methods This was an international, multicenter, prospective, cross-sectional observational study. At each center, 10 inclusions, stratified by CD duration and location, were planned. For each patient, the digestive tract was divided into 4 organs, upper tract, small bowel, colon/rectum, anus, and subsequently into segments, explored systematically by magnetic resonance imaging (MRI), and by endoscopies in relation to disease location. For each segment, investigators retrieved information on previous surgical procedures, identified predefined strictures and penetrating lesions of maximal severity (grades 1-3) at each organ investigational method (gastroenterologist and radiologist for MRI), provided segmental damage evaluation ranging from 0.0 to 10.0 (complete resection). Organ resection-free cumulative damage evaluation was then calculated from the sum of segmental damages. Then, investigators provided a 0-10 global damage evaluation from the 4 organ standardized cumulative damage evaluations. Simple linear regressions of investigator damage evaluations on their corresponding Lémann index were studied, as well as calibration plots. Finally, updated Lémann index was derived through multiple linear mixed models applied to combined development and validation samples. Results In 15 centers, 134 patients were included. Correlation coefficients between investigator damage evaluations and Lémann indexes were above 0.80. When analyzing data in 272 patients from both samples and 27 centers, the unbiased correlation estimates were 0.89, 0,97, 0,94, 0.81, 0.91 for the 4 organs and globally, and stable when applied to one sample or the other. Conclusions The updated Lémann index is a well-established index to assess cumulative bowel damage in Crohn’s disease that can be used in epidemiological studies and disease modification trials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology
ISSN
0016-5085
e-ISSN
—
Volume of the periodical
161
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
853-864
UT code for WoS article
000687968400022
EID of the result in the Scopus database
2-s2.0-85112754959