Inter-placental variability is not a major factor affecting the healing efficiency of amniotic membrane when used for treating chronic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F23%3A00009712" target="_blank" >RIV/00023884:_____/23:00009712 - isvavai.cz</a>

Result on the web

<a href="https://link-springer-com.ezproxy.lib.cas.cz/content/pdf/10.1007/s10561-023-10096-y.pdf" target="_blank" >https://link-springer-com.ezproxy.lib.cas.cz/content/pdf/10.1007/s10561-023-10096-y.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10561-023-10096-y" target="_blank" >10.1007/s10561-023-10096-y</a>

Result language

angličtina

Original language name

Inter-placental variability is not a major factor affecting the healing efficiency of amniotic membrane when used for treating chronic

Original language description

This study aimed to evaluate the efficacy of cryopreserved amniotic membrane (AM) grafts in chronic wound healing, including the mean percentage of wound closure per one AM application, and to determine whether the healing efficiency differs between AM grafts obtained from different placentas. A retrospective study analyzing inter-placental differences in healing capacity and mean wound closure after the application of 96 AM grafts prepared from nine placentas. Only the placentas from which the AM grafts were applied to patients suffering from long-lasting non-healing wounds successfully healed by AM treatment were included. The data from the rapidly progressing wound-closure phase (p-phase) were analyzed. The mean efficiency for each placenta, expressed as an average of wound area reduction (%) seven days after the AM application (baseline, 100%), was calculated from at least 10 applications. No statistical difference between the nine placentas' efficiency was found in the progressive phase of wound healing. The 7-day average wound reduction in particular placentas varied from 5.70 to 20.99% (median from 1.07 to 17.75) of the baseline. The mean percentage of wound surface reduction of all analyzed defects one week after the application of cryopreserved AM graft was 12.17 +/- 20.12% (average +/- SD). No significant difference in healing capacity was observed between the nine placentas. The data suggest that if there are intra- and inter-placental differences in AM sheets' healing efficacy, they are overridden by the actual health status of the subject or even the status of its individual wounds.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell And Tissue Banking

ISSN

1389-9333

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

779-788

UT code for WoS article

000994735600001

EID of the result in the Scopus database

2-s2.0-85160328599