MicroRNAs and other biomarkers of atrial fibrillation in ischemic stroke patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F24%3A00009887" target="_blank" >RIV/00023884:_____/24:00009887 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/24:10486786 RIV/00064203:_____/24:10486786

Result on the web

<a href="https://journals.lww.com/md-journal/fulltext/2024/10250/micrornas_and_other_biomarkers_of_atrial.54.aspx" target="_blank" >https://journals.lww.com/md-journal/fulltext/2024/10250/micrornas_and_other_biomarkers_of_atrial.54.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MD.0000000000040165" target="_blank" >10.1097/MD.0000000000040165</a>

Result language

angličtina

Original language name

MicroRNAs and other biomarkers of atrial fibrillation in ischemic stroke patients

Original language description

This study aimed to evaluate the ability of selected microRNAs as biomarkers of atrial fibrillation (AF) in ischemic stroke patients in comparison with other established biochemical biomarkers. A prospective case-control study of consecutive ischemic stroke patients with AF admitted to a comprehensive stroke center was conducted. The control group consisted of patients with ischemic stroke with no AF detected on prolonged (at least 3 weeks) Holter ECG monitoring. As potential biomarkers of AF, we analyzed the plasma levels of microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) and 13 biochemical biomarkers at admission. The predictive accuracy of biomarkers was assessed by calculating the area under the receiver operating characteristic curve. The data of 117 patients were analyzed (61 with AF, 56 with no AF, 46% men, median age 73 years, median National Institutes of Health Stroke Scale 6). Biochemical biomarkers (N-terminal pro-B-type natriuretic peptide [NT-proBNP], high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and total triglycerides) were significantly associated with AF. NT-proBNP had the best diagnostic performance for AF with area under the receiver operating characteristic curve 0.92 (95%, CI 0.86-0.98); a cutoff value of >528 ng/L had a sensitivity of 79% and a specificity of 97%. None of the other biomarkers, including microRNAs, was associated with AF. Conventional biochemical biomarkers (NT-proBNP, high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and triglycerides), but not microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) were significantly associated with AF in our ischemic stroke cohort.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NV19-08-00362" target="_blank" >NV19-08-00362: Evaluation of atherosclerotic plaque stability in carotids using digital image analysis of ultrasound images</a><br>

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicine

ISSN

0025-7974

e-ISSN

—

Volume of the periodical

103

Issue of the periodical within the volume

43

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

001345441900069

EID of the result in the Scopus database

2-s2.0-85208082115