Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F24%3A00009923" target="_blank" >RIV/00023884:_____/24:00009923 - isvavai.cz</a>
Result on the web
<a href="https://thejns.org/view/journals/j-neurosurg/140/5/article-p1233.xml" target="_blank" >https://thejns.org/view/journals/j-neurosurg/140/5/article-p1233.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3171/2023.8.JNS231231" target="_blank" >10.3171/2023.8.JNS231231</a>
Alternative languages
Result language
angličtina
Original language name
Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis
Original language description
OBJECTIVE The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM). METHODS Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53.5%) had solitary tumors, although 10.7% had > 5 tumors. The median tumor volume was 2.7 cm(3) (IQR 0.22-8.1 cm(3) ), and the median margin dose was 20 Gy (IQR 18-22 Gy). RESULTS The 3 -year LC and OS rates were 72% and 20%, respectively. Symptomatic adverse radiation effects occurred in 1.6% of patients. In the multivariate analysis, age > 65 years and tumor volume > 4.0 cm 3 were significant predictors of tumor progression (hazard ratio [HR] 2.6, 95% CI 1.4-4.9; p = 0.003 and HR 3.4, 95% CI 1.7-6.9; p < 0.001, respectively). Better performance status (Karnofsky Performance Scale score > 80) was associated with a reduced risk of tumor progression (HR 0.38, 95% CI 0.19-0.73; p = 0.004). Patient age > 62 years (HR 1.6, 95% CI 1.1-2.3; p = 0.03) and the presence of active extracranial disease (HR 1.7, 95% CI 1.1-2.4; p = 0.009) were significantly associated with worse OS. CONCLUSIONS Stereotactic radiosurgery offers a high LC rate and a low rate of symptomatic adverse radiation effects for the majority of CRBMs. The OS and LC favored younger patients with high functional performance scores and inactive extracranial disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurosurgery
ISSN
0022-3085
e-ISSN
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Volume of the periodical
140
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1233-1242
UT code for WoS article
001241850800004
EID of the result in the Scopus database
2-s2.0-85192112804