Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F24%3A00009935" target="_blank" >RIV/00023884:_____/24:00009935 - isvavai.cz</a>
Result on the web
<a href="https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1990-2861" target="_blank" >https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1990-2861</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/a-1990-2861" target="_blank" >10.1055/a-1990-2861</a>
Alternative languages
Result language
angličtina
Original language name
Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol
Original language description
Background Stereotactic radiosurgery (SRS) and resection are treatment options for patients with facial nerve schwannomas without mass effect.Objective This article evaluates outcomes of patients treated with SRS versus resection + SRS.Method We retrospectively compared 43 patients treated with SRS to 12 patients treated with resection + SRS. The primary study outcome was unfavorable combined endpoint, defined as worsening or new clinical symptoms, and/or tumor radiological progression. SRS (38.81 & PLUSMN; 5.3) and resection + SRS (67.14 & PLUSMN; 11.8) groups had similar clinical follow-ups.Results At the time of SRS, the tumor volumes of SRS (mean & PLUSMN; standard error; 1.83 & PLUSMN; 0.35 mL) and resection + SRS (2.51 & PLUSMN; 0.75 mL) groups were similar. SRS (12.15 & PLUSMN; 0.08 Gy) and resection + SRS (12.16 & PLUSMN; 0.14 Gy) groups received similar radiation doses. SRS group (42/43, 98%) had better local tumor control than the resection + SRS group (10/12, 83%, p = 0.04). Most of SRS (32/43, 74%) and resection + SRS (10/12, 83%) group patients reached a favorable combined endpoint following SRS ( p = 0.52). Considering surgical associated side effects, only 2/10 patients of the resection + SRS group reached a favorable endpoint ( p < 0.001).Patients of SRS group, who are > 34 years old ( p = 0.02), have larger tumors (> 4 mL, 0.04), internal auditory canal (IAC) segment tumor involvement ( p = 0.01) were more likely to reach an unfavorable endpoint. Resection + SRS group patients did not show such a difference.Conclusion While resection is still needed for larger tumors, SRS offers better clinical and radiological outcomes compared to resection followed by SRS for facial schwannomas. Younger age, smaller tumors, and non-IAC situated tumors are factors that portend a favorable outcome.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurological Surgery Part B-Skull Base
ISSN
2193-6331
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
75-80
UT code for WoS article
000906049500003
EID of the result in the Scopus database
2-s2.0-85144760866