Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010172" target="_blank" >RIV/00023884:_____/25:00010172 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10505506 RIV/00216208:11120/25:43929080 RIV/00064165:_____/25:10505506
Result on the web
<a href="https://www-nature-com.ezproxy.lib.cas.cz/articles/s41531-025-01174-x" target="_blank" >https://www-nature-com.ezproxy.lib.cas.cz/articles/s41531-025-01174-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41531-025-01174-x" target="_blank" >10.1038/s41531-025-01174-x</a>

Result language
angličtina
Original language name
Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD
Original language description
Quantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in alpha-synucleinopathies, especially within the midbrain. This study evaluated their potential to predict phenoconversion to overt synucleinopathy in 79 patients with isolated REM sleep behavior disorder (iRBD) followed annually over 5.6 +/- 3.0 years. Phenoconversion, defined by emergence of parkinsonism or dementia, occurred in 21 patients. Baseline QSM and DTI data were analyzed to identify regional brain differences, revealing increased magnetic susceptibility and fractional anisotropy (FA) in the bilateral cerebral peduncle of phenoconverters. Increased magnetic susceptibility and FA within this region were associated with higher phenoconversion risk (FA: hazard ratio (HR) = 1.84, susceptibility: HR = 1.67). Their combined score predicted phenoconversion with accuracy similar to dopamine-transporter imaging (HR 2.58 vs 2.85). Findings suggest that increased susceptibility and FA in the cerebral peduncle may serve as biomarkers of early phenoconversion, potentially reflecting compensatory neuroplastic changes in subthalamo-pallidal pathways.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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