Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010173" target="_blank" >RIV/00023884:_____/25:00010173 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/25:00388911 RIV/00216208:11110/25:10494758 RIV/00216208:11120/25:43928138 RIV/00064165:_____/25:10494758
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/39986202/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/39986202/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nicl.2025.103750" target="_blank" >10.1016/j.nicl.2025.103750</a>
Alternative languages
Result language
angličtina
Original language name
Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area
Original language description
Introduction: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is a well-established, effective treatment for dystonia. Substantial variability of therapeutic success has been the one of the drivers of an ongoing debate about proper stimulation site and settings, with several indications of the notional sweet spot pointing to the lower GPi or even subpallidal area. Methods: The presented patient-blinded, random-order study with cross-sectional verification against healthy controls enrolled 17 GPi DBS idiopathic, cervical or generalised dystonia patients to compare the effect of the stimulation in the upper and lower GPi area, with the focus on sensorimotor network connectivity and local activity measured using functional magnetic resonance. Results: Stimulation brought both these parameters to levels closer to the state detected in healthy controls. This effect was much more pronounced during the stimulation in the lower GPi area or beneath it than in slightly higher positions, with stimulation-related changes detected by both metrics of interest in the sensorimotor cortex, striatum, thalamus and cerebellum. Conclusions: All in all, this study not only replicated the results of previous studies on GPi DBS as a modality restoring sensorimotor network connectivity and local activity in dystonia towards the levels in healthy population, but also showed that lower GPi area or even subpallidal structures, be it white matter or even small, but essential nodes in the zona incerta as nucleus basalis of Meynert, are important regions to consider when programming DBS in dystonia patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NeuroImage: Clinical
ISSN
2213-1582
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
February
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
001431233800001
EID of the result in the Scopus database
2-s2.0-85218116523