Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010187" target="_blank" >RIV/00023884:_____/25:00010187 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10504258 RIV/00064203:_____/25:10504258 RIV/00064165:_____/25:10504258

Result on the web

<a href="https://www.mdpi.com/2073-4409/14/19/1504" target="_blank" >https://www.mdpi.com/2073-4409/14/19/1504</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells14191504" target="_blank" >10.3390/cells14191504</a>

Result language

angličtina

Original language name

Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview

Original language description

A subset of chondrocytes in various human cartilage tissues, including neoplastic, regenerative, and normal cartilage, expresses alpha-smooth muscle actin (alpha-SMA), a protein typically found in smooth muscle cells. These alpha-SMA-containing chondrocytes, termed myochondrocytes and myochondroblasts, may play important roles in cartilage physiology, regeneration, and structural integrity, particularly in auricular and articular cartilage. This review synthesizes current knowledge regarding the terminology, distribution, and biological significance of these cells across normal, osteoarthritic, transplanted, and neoplastic cartilage. We summarize key findings from immunohistochemical studies using markers such as S-100, alpha-SMA, and SOX9, along with ultrastructural confirmation of myofilament bundles via electron microscopy. Current evidence suggests that myochondrocytes exhibit enhanced regenerative potential and contribute to matrix remodeling. Furthermore, their presence reflects the inherent cellular heterogeneity of cartilage, potentially arising from transdifferentiation processes involving fibroblasts, mesenchymal stem cells, or chondroblasts. Finally, TGF-beta 1 and PDGF-BB are identified as a critical modulator of alpha-SMA expression and chondrocyte phenotype. A deeper understanding of nature and function of myochondrocytes and myochondroblasts may improve interpretations of cartilage pathology and inform strategies for tissue engineering and cartilage repair. This review highlights the need for further investigation into the molecular regulation and functional roles of these cells in both physiological and pathological contexts.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/LM2023033" target="_blank" >LM2023033: Czech biobank network</a><br>

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

19

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

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UT code for WoS article

001593509300001

EID of the result in the Scopus database

2-s2.0-105018648044