Minor cereals exhibit superior antioxidant effects on human epithelial cells compared to common wheat cultivars
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F19%3A00005364" target="_blank" >RIV/00027006:_____/19:00005364 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0733521018304430" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0733521018304430</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcs.2018.12.006" target="_blank" >10.1016/j.jcs.2018.12.006</a>
Alternative languages
Result language
angličtina
Original language name
Minor cereals exhibit superior antioxidant effects on human epithelial cells compared to common wheat cultivars
Original language description
In the present study, various minor cereals including rye, oat, spelt, primitive and wild wheat species (20 genotypes each) were tested for their antioxidative effects in cell biological studies, and the effects were compared with the effects of 12 common wheat genotypes. Ethanol soluble extracts of grains were used and studied in human cancer-derived cell lines including HeLa (cervical) and HCT116 (colorectal) cell lines by analyzing cellular levels of reactive oxygen species (ROS), mitochondrial health, DNA damage and cell survival. The cereal genotypes were also examined for the total phenolic concentration (TPC) and for the relationship between oxidative cell damage and TPC values. Most genotypes of the minor cereal species showed superior antioxidant effects in human cell cultures compared to the common wheat genotypes. Many of the minor cereal genotypes with high antioxidant capacities protected DNA and mitochondrial damage and prevented cell death in HeLa cells and colon-derived HCT116 human epithelial cells. There was no significant relationship between TPC values and oxidative cell damage. However, common wheat genotypes had, on average, lower TPC values. The results show that minor cereals contain potentially high levels of certain antioxidant substances which might be useful in preventing oxidative damage in cellular systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cereal Science
ISSN
0733-5210
e-ISSN
1095-9963
Volume of the periodical
85
Issue of the periodical within the volume
JAN 2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
143-152
UT code for WoS article
000457950900022
EID of the result in the Scopus database
2-s2.0-85059325868