Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F22%3A10175135" target="_blank" >RIV/00027006:_____/22:10175135 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/21:73607400
Result on the web
<a href="https://www.tandfonline.com/toc/gnpl20/36/11" target="_blank" >https://www.tandfonline.com/toc/gnpl20/36/11</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14786419.2021.1925275" target="_blank" >10.1080/14786419.2021.1925275</a>
Alternative languages
Result language
angličtina
Original language name
Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina
Original language description
Clinopodium alpinum subsp. orontium (K.Maly) Govaerts and Thymus bracteosus Vis. ex Benth. are endemic Lamiaceae species in Bosnia and Herzegovina with rather limited data about their cytotoxic and genotoxic effects. This study aimed to analyse phenolic compounds composition of C. alpinum subsp. orontium and T. bracteosus aqueous and dimethyl sulphoxide (DMSO) extracts and their cytotoxic and genotoxic potential in human peripheral blood lymphocyte cultures. Among 33 analytes, 17 were identified and quantified in the examined extracts with the rosmarinic and chlorogenic acids as main constituents. Genotoxic effects of extracts from both species are proven at the highest applied dose. T. bracteosus extracts and DMSO as a solvent exhibited stronger genotoxic potential that should be further investigated in tumour cell lines. Nevertheless, non-endemic species with similar phenolic composition and bioactivity should be the first choice for medicinal purposes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)
Result continuities
Project
<a href="/en/project/LO1204" target="_blank" >LO1204: Sustainable development of research in the Centre of the Region Haná</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Natural Product Research
ISSN
1478-6419
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2888-2892
UT code for WoS article
000652791200001
EID of the result in the Scopus database
2-s2.0-85106246682