Cis-Δ9-tetrahydrocannabinolic acid occurrence in Cannabis sativa L.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F22%3A10175258" target="_blank" >RIV/00027006:_____/22:10175258 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/22:73616561

Result on the web

<a href="https://www.sciencedirect.com/journal/journal-of-pharmaceutical-and-biomedical-analysis/vol/219/suppl/C" target="_blank" >https://www.sciencedirect.com/journal/journal-of-pharmaceutical-and-biomedical-analysis/vol/219/suppl/C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpba.2022.114958" target="_blank" >10.1016/j.jpba.2022.114958</a>

Result language

angličtina

Original language name

Cis-Δ9-tetrahydrocannabinolic acid occurrence in Cannabis sativa L.

Original language description

Cannabidiolic acid (CBDA) and trans-Δ9-tetrahydrocannabinolic acid (trans-Δ9-THCA) are known to be the major phytocannabinoids in Cannabis sativa L., along with their decarboxylated derivatives cannabidiol (CBD) and trans-Δ9-tetrahydrocannabinol (trans-Δ9-THC). The cis isomer of Δ9-THC has been recently identified, characterized and quantified in several Cannabis sativa varieties, which had been heated (decarboxylated) before the analysis. Since decarboxylation alters the original phytocannabinoids composition of the plant, this work reports the identification and characterization of the carboxylated precursor cis-Δ9-THCA. The compound was also synthesized and used as analytical standard for the development and validation of a liquid chromatography coupled to high resolution mass spectrometry-based method for its quantification in ten Cannabis sativa L. samples from different chemotypes. The highest concentrations of cis-Δ9-THCA were found in CBD-rich varieties, lower levels were observed in cannabigerol (CBG)-rich varieties (chemotype IV) and in those varieties with a balanced level of both CBD and THC (chemotype III), while its levels were not detectable in cannabichromene (CBC)-rich varieties (chemotype VI). The presence of the cis isomer of THC and THCA raises the question on whether to include or not this species in the calculation of the total amount of THC to classify a cannabis variety as a drug-type or a fiber-type (hemp).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Project

<a href="/en/project/EF18_053%2F0016953" target="_blank" >EF18_053/0016953: Mobility of researchers to support new trends and methods of agricultural research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ISSN

0731-7085

e-ISSN

—

Volume of the periodical

219

Issue of the periodical within the volume

SEP 20 2022

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

114958

UT code for WoS article

000843015300003

EID of the result in the Scopus database

2-s2.0-85135323878