Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F24%3A10177081" target="_blank" >RIV/00027006:_____/24:10177081 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15640/24:73624565
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s11130-023-01131-0.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s11130-023-01131-0.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11130-023-01131-0" target="_blank" >10.1007/s11130-023-01131-0</a>

Result language
angličtina
Original language name
Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities
Original language description
Onosma riedliana Binzet & Orcan, a traditionally used plant species, has been explored for its therapeutic potential in this study. The work presented here is the first report on the phenolic profile and biological activity of this species. Three extracts of varying polarity were prepared, with the methanolic extract containing the highest phenolic content (97.62 +/- 0.20 mgGAE/g). Key phenolic compounds identified included pinoresinol, hesperidin, 4-hydroxybenzoic acid, and p-coumaric acid. The methanolic extract exhibited exceptional antioxidant properties, rivaling Trolox as a positive control, primarily attributed to hesperidin and luteolin. Moreover, the ethyl acetate extract demonstrated remarkable inhibition of cholinesterase and tyrosinase enzymes, while the methanolic extract displayed potent activity against carbohydrate hydrolytic enzymes, alpha-amylase and alpha-glucosidase. Again, phenolic compounds were shown to be responsible for the inhibition of cholinesterases and tyrosinase, but not for alpha-amylase and alpha-glucosidase. These findings underscore Onosma riedliana's potential for incorporation into diverse pharmaceutical formulations, given its multifaceted bioactivity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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