Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F19%3AN0000053" target="_blank" >RIV/00027014:_____/19:N0000053 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1387/ijdb.180329jf" target="_blank" >http://dx.doi.org/10.1387/ijdb.180329jf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1387/ijdb.180329jf" target="_blank" >10.1387/ijdb.180329jf</a>

Result language
angličtina
Original language name
Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine
Original language description
Mammalian oocytes/zygotes contain atypical nucleoli that are composed exclusively of a dense fibrillar material. It has been commonly accepted that these nucleoli serve as a repository of components that are used later on, as the embryo develops, for the construction of typical tripartite nucleoli. Indeed, when nucleoli were removed from immature oocytes (enucleolation) and these oocytes were then matured, fertilized or parthenogenetically activated, development of the produced embryos ceased after one or two cleavages with no detectable nucleoli in nuclei. This indicated that zygotic nucleoli originate exclusively from oocytes, i.e. are maternally inherited. Recently published results, however, do not support this developmental biology dogma and demonstrate that maternal nucleoli in one-cell stage embryos are necessary only during a very short time period after fertilization when they serve as a major heterochromatin organizing structures. Nevertheless, it still remains to be determined, which other functions/roles the atypical oocyte/zygote nucleoli eventually have.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)

Project
<a href="/en/project/GA17-08605S" target="_blank" >GA17-08605S: Nuclear and cytoplasmic determinants involved in the regulation of mammalian oocyte maturation and embryo development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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