Hydrogen Sulfide Impairs Meiosis Resumption in Xenopus laevis Oocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F20%3AN0000072" target="_blank" >RIV/00027014:_____/20:N0000072 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/20:81072 RIV/00216208:11140/20:10403491
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=5&SID=D3vFDVS6MmhCaxyr9tU&page=1&doc=17" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=5&SID=D3vFDVS6MmhCaxyr9tU&page=1&doc=17</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells9010237" target="_blank" >10.3390/cells9010237</a>
Alternative languages
Result language
angličtina
Original language name
Hydrogen Sulfide Impairs Meiosis Resumption in Xenopus laevis Oocytes
Original language description
The role of hydrogen sulfide (H2S) is addressed in Xenopuslaevis oocytes. Three enzymes involvedinH2Smetabolism,cystathionineβ-synthase,cystathionineγ-lyase,and3-mercaptopyruvate sulfurtransferase, were detected in prophase I and metaphase II-arrested oocytes and drove an accelerationofoocytemeiosisresumptionwheninhibited. Moreover,meiosisresumptionisassociated with a significant decrease in endogenous H2S. On another hand, a dose-dependent inhibition was obtained using the H2S donor, NaHS (1 and 5 mM). NaHS impaired translation. NaHS did not inducethedissociationofthecomponentsoftheM-phasepromotingfactor(MPF),cyclinBandCdk1, nor directly impacted the MPF activity. However, the M-phase entry induced by microinjection of metaphase II MPF-containing cytoplasm was diminished, suggesting upstream components of the MPF auto-amplification loop were sensitive to H2S. Superoxide dismutase and catalase hindered the effects of NaHS, and this sensitivity was partially dependent on the production of reactive oxygen species (ROS). In contrast to other species, no apoptosis was promoted. These results suggest a contribution of H2S signaling in the timing of amphibian oocytes meiosis resumption.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
—
Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
Article Number 237
UT code for WoS article
000515398200237
EID of the result in the Scopus database
2-s2.0-85098467490