Zinc phosphate-based nanoparticles as alternatives to zinc oxide in diet of weaned piglets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F20%3AN0000076" target="_blank" >RIV/00027014:_____/20:N0000076 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16810/20:43878427

Result on the web

<a href="https://jasbsci.biomedcentral.com/track/pdf/10.1186/s40104-020-00458-x" target="_blank" >https://jasbsci.biomedcentral.com/track/pdf/10.1186/s40104-020-00458-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40104-020-00458-x" target="_blank" >10.1186/s40104-020-00458-x</a>

Result language

angličtina

Original language name

Zinc phosphate-based nanoparticles as alternatives to zinc oxide in diet of weaned piglets

Original language description

Background The high doses of zinc oxide (ZnO) administered orally to piglets for the prevention of diarrhea and increase of growth rate can contaminate pig farms and the surrounding environment. Therefore, there is a need to find a replacement of high doses of dietary ZnO with an equally effective alternative. In the present study, the effect of two formulations of zinc phosphate-based nanoparticles (ZnA and ZnC NPs) on growth performance, intestinal microbiota, antioxidant status, and intestinal and liver morphology was evaluated. A total of 100 weaned piglets were randomly divided into 10 equal groups with the base diet (control) or the base diet supplemented with ZnA, ZnC, or ZnO at concentrations 500, 1000, and 2000 mg Zn per kilogram of diet. Supplements were given to animals for 10 days. Fecal samples were collected on day 0, 5, 10 and 20. At the end of the treatment (day 10), three piglets from each group were sacrificed and analyzed. Results Comparing to that of control, the significantly higher piglet weight gain was observed in all piglet groups fed with ZnA (P < 0.05). Differences in the total aerobic bacteria and coliform counts in piglet feces after NPs supplementation compared to that of control and ZnO groups were also found (P < 0.05). The majority of aerobic culturable bacteria from the feces represented Escherichia (28.57-47.62%), Enterococcus (3.85-35.71%), and Streptococcus (3.70-42.31%) spp. A total of 542 Escherichia coli isolates were screened for the virulence genes STa, STb, Stx2, F4, and F18. The substantial occurrence of E. coli virulence factors was found on day 5, mainly in fimbrillary antigen and thermostable toxins, except for piglets fed by ZnC. Zn treatment decreased Zn blood levels in piglets fed with ZnO and ZnA (500 mg/kg) and increased in ZnC (2000 mg/kg) compared to that of control (P < 0.05).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40401 - Agricultural biotechnology and food biotechnology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Animal Science and Biotechnology

ISSN

2049-1891

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

Article Number 59

UT code for WoS article

000540838100001

EID of the result in the Scopus database

2-s2.0-85087054575