Candidate genes for congenital malformations in pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F21%3AN0000238" target="_blank" >RIV/00027014:_____/21:N0000238 - isvavai.cz</a>
Result on the web
<a href="http://acta.fapz.uniag.sk/journal/index.php/on_line/article/view/982" target="_blank" >http://acta.fapz.uniag.sk/journal/index.php/on_line/article/view/982</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15414/afz.2021.24.04.309-314" target="_blank" >10.15414/afz.2021.24.04.309-314</a>

Result language
angličtina
Original language name
Candidate genes for congenital malformations in pigs
Original language description
Congenital malformations occur in numerous pig breeding programs. Clinical symptoms, etiopathogenesis and candidate genes of the most critical congenital malformations in pigs were briefly overviewed in the study. Based on the recent literature, identifying and evaluating the genomic regions associated with defects, such as splay legs syndrome, hernias, cryptorchidism, atresia ani, kyphosis, intersexuality, and malignant melanoma, can enhance the selection response. As promising genes were published e.g. NREP, FBXO32, and HOMER1 for splay leg syndrome, SRC, OSM, COL family, and CGRP for hernias, GNRHR, GATA2, and RLF for cryptorchidism, and GLI2 for atresia ani. Potential candidate genes associated with defects were mainly detected in literature by the genome-wide association approach. Reviewing the studies and following the suggestions in some of papers it is indicated the necessity for molecular and more comprehensive evaluation in terms of the sample standardisation and accurate phenotyping of a broad spectrum of populations and breeds. Moreover, knowledge transmission among all livestock species and humans is recommended in literature to better understand malformation biology.
Czech name
—
Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
40203 - Husbandry

Project
<a href="/en/project/QK1910217" target="_blank" >QK1910217: Creation of a reference population and development of methods for estimating genomic breeding values of pig traits included into the Czech National Breeding Program.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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