Haplotype disequilibrium in the TLR genes of Czech Red Pied cattle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F23%3A10005815" target="_blank" >RIV/00027014:_____/23:10005815 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10466824
Result on the web
<a href="https://www.mdpi.com/1424-2818/15/7/811" target="_blank" >https://www.mdpi.com/1424-2818/15/7/811</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/d15070811" target="_blank" >10.3390/d15070811</a>
Alternative languages
Result language
angličtina
Original language name
Haplotype disequilibrium in the TLR genes of Czech Red Pied cattle
Original language description
Hybrid resequencing using HiSeq and PacBio technologies of the antibacterial innate immune genes coding for toll-like receptors, namely TLR1, TLR2, TLR4, TLR5, and TLR6, in Czech Red Pied cattle (Czech Simmental) allowed us to determine haplotypes formed by the polymorphisms present. Directly determined haplotypes in the range of the large proximal amplicon in TLR2 formed two clusters in the network tree graph. Consistently, the distribution of the statistically reconstructed haplotypes was similar both in TLR2 and in other TLRs. Only the limited diversity of TLR1 did not allow for any assumption. The stability of this phenomenon cannot be ascribed to the historical origin but rather to a long-term effect of balancing selection. The equilibrium might be based on two different essential functions performed by the TLR genes or their products. The formation of two kinds of heterodimers by the TLR2 product, namely, TLR2/TLR1 and TLR2/TLR6 with different ligand specificities, is considered to be a particular case.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40203 - Husbandry
Result continuities
Project
<a href="/en/project/QJ1610489" target="_blank" >QJ1610489: Occurence of genetic factors for infection resistance in selected breeds of dairy cattle</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diversity-Basel
ISSN
1424-2818
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
811
UT code for WoS article
001035280200001
EID of the result in the Scopus database
2-s2.0-85166205742