Composite blood vessel substitute and the method for producing it.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F23%3AN0000088" target="_blank" >RIV/00027022:_____/23:N0000088 - isvavai.cz</a>

Result on the web

<a href="https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&locale=en_EP&CC=EP&NR=3434292B1&KC=B1#" target="_blank" >https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&locale=en_EP&CC=EP&NR=3434292B1&KC=B1#</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Composite blood vessel substitute and the method for producing it.

Original language description

The present invention relates to a composite vascular substitute, in particular for flow rates under 100 ml/min and inner diameters under 6 mm, which contains a non-resorbable knitted fabric layer (2), which is provided on the inner and outer sides with a collagen compound coating of freshwater fish - Czech carp. The non-resorbable knitted fabric compound (2) is preferably placed on a self-supporting resorbable collagen compound layer (1), wherein the non-resorbable layer (2) is covered with an intermediate collagen compound layer (4) overlaid with an outer, resorbable collagen compound layer (3). Furthermore, it relates to the method for producing this vascular substitute, wherein the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the non-resorbable knitted fabric layer 2 is integrated in one collagen compound layer to make a collagen compound coating on the inner and outer sides of the non-resorbable knitted fabric layer 2, or the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the collagen compound is extruded to make the inner resorbable layer (1) in the form of a tube that is dried at the room temperature until pliable, and the inner resorbable layer (1) is overlaid with the non-resorbable knitted fabric layer (2), on which the outer resorbable layer (3) of collagen compound with a collagen concentration of 3 to 12% by weight is extruded, and the vascular substitutes are dried at 15 to 30 °C for 15 to 30 hours until pliable, and then the vascular substitutes are hardened with 1.5 to 3.2% resin for 3 to 10 minutes and then they are dried and softened up in a 15 to 30% glycerine bath for 15 to 25 minutes.

Czech name

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Czech description

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Type

P - Patent

CEP classification

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OECD FORD branch

30401 - Health-related biotechnology

Project

<a href="/en/project/NT13302" target="_blank" >NT13302: THE OPTIMALIZATION OF PHYSICAL CHARACTERISTICS OF VASCULAR SUBSTITUTES FOR LOW FLOW</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Patent/design ID

EP3434292 (B1)

Publisher

EPO_1 -

Publisher name

European Patent Office

Place of publication

Munich, The Hague, Berlin, Vienna, Brussels

Publication country

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Date of acceptance

Aug 23, 2023

Owner name

ČVUT; UK Praha; VFN Praha; VÚPP, v.v.i.

Method of use

A - Výsledek využívá pouze poskytovatel

Usage type

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence