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GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F07%3A%230000218" target="_blank" >RIV/00027162:_____/07:#0000218 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/07:00095685 RIV/68378041:_____/07:00342040

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution

  • Original language description

    In these studies DNA damage was measured using the Sperm Chromatin Structure Assay (SCSA) wherein the percentage of sperm with abnormal chromatin/fragmented DNA is determined and expressed as % DNA DFI Fragmentation Index (%DFI). Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Consequently they are more susceptible to the effects of air pollution on sperm chromatin. Using a longitudinal study design in which men provided semen samples during periods of both low (baseline) and episodically high air pollution, this study revealed a statistically significant association between GSTM1 null genotype and increased SCSA-defined %DFI (beta=0.309; 95% CI: 0.129, 0.489). Furthermore, GSTM1 null men also showed higher %DFI in response to exposure to intermittent air pollution.

  • Czech name

    Genotyp GSTM1 ovlivňuje citlivost mužů k poškození DNA ve spermiích při expozici znečistěným ovzduším

  • Czech description

    Byla provedena studie testující vztah mezi genotypem GSTM1 a citlivostí chromatinu spermií mužů k expozici karcinogenními PAH. Získané výsledky ukazují, že muži, kteří jsou homozygoti, pro deleci GSTM1 genu mají vyšší riziko fragmentace chromatinu ve spermiích, pokud jsou exponováni c-PAH.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis

  • ISSN

    0027-5107

  • e-ISSN

  • Volume of the periodical

    625

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    9

  • Pages from-to

    20-28

  • UT code for WoS article

  • EID of the result in the Scopus database