GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F07%3A%230000218" target="_blank" >RIV/00027162:_____/07:#0000218 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/07:00095685 RIV/68378041:_____/07:00342040
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution
Original language description
In these studies DNA damage was measured using the Sperm Chromatin Structure Assay (SCSA) wherein the percentage of sperm with abnormal chromatin/fragmented DNA is determined and expressed as % DNA DFI Fragmentation Index (%DFI). Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Consequently they are more susceptible to the effects of air pollution on sperm chromatin. Using a longitudinal study design in which men provided semen samples during periods of both low (baseline) and episodically high air pollution, this study revealed a statistically significant association between GSTM1 null genotype and increased SCSA-defined %DFI (beta=0.309; 95% CI: 0.129, 0.489). Furthermore, GSTM1 null men also showed higher %DFI in response to exposure to intermittent air pollution.
Czech name
Genotyp GSTM1 ovlivňuje citlivost mužů k poškození DNA ve spermiích při expozici znečistěným ovzduším
Czech description
Byla provedena studie testující vztah mezi genotypem GSTM1 a citlivostí chromatinu spermií mužů k expozici karcinogenními PAH. Získané výsledky ukazují, že muži, kteří jsou homozygoti, pro deleci GSTM1 genu mají vyšší riziko fragmentace chromatinu ve spermiích, pokud jsou exponováni c-PAH.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
ISSN
0027-5107
e-ISSN
—
Volume of the periodical
625
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
20-28
UT code for WoS article
—
EID of the result in the Scopus database
—