Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000599" target="_blank" >RIV/00027162:_____/08:#0000599 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse
Original language description
In previous work, we found significant associations of horse chromosome 15 microsatellite markers HMSO1 and HTG06 with two horse infections, Rhodococcus equi and Lawsonia intracellularis, respectively. Interleukin-1 beta subunit and interleukin-1 receptor antagonist encoding genes (IL1B and IL1RN) could be considered as candidate genes. Therefore, we identified single nucleotide polymorphisms (SNPs) within three interleukin-1 beta functionally related genes: IL1B, IL1RN and Casp1 (interleukin-1 beta converting enzyme/caspasel encoding gene). Using appropriate restriction fragment length polymorphism (PCR-RFLP) and/or single strand conformation polymorphism (PCR-SSCP) markers, their associations with the two infections by genotyping foals from the original study were tested. A statistically significant association between an intronic SNP of the Casp1 gene with R. equi infection was found. The IL1RN gene was physically localized by fluorescence in-situ hybridization to 15q13-q14.
Czech name
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Czech description
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Project
<a href="/en/project/GA523%2F06%2F1402" target="_blank" >GA523/06/1402: Immunity-related genes in Equids: genetic diversity and comparative genomics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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