Liposomal formulation of alpha-tocopheryl maleamide: In vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000491" target="_blank" >RIV/00027162:_____/09:#0000491 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/09:00340455

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Liposomal formulation of alpha-tocopheryl maleamide: In vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice

Original language description

The vitamin E analogue alpha-tocopheryl succinate (a-TOS) is an efficient anti-cancer drug. Improved efficacy was achieved through the synthesis of alpha-tocopheryl maleamide (a-TAM), an esterase-resistant analogue of alpha -tocopheryl maleate. In vitrotests demonstrated significantly higher cytotoxicity of a-TAM towards cancer cells compared to a-TOS and other analogues prone to esterase-catalyzed hydrolysis.We developed lyophilized liposomal formulations of both a-TOS and a-TAM to solve the problem with solubility of free drugs. Liposomal formulation of a-TAM demonstrated anti-cancer activity at levels 10-fold lower than those of a-TOS. Remarkably, neither acute toxicity nor immunotoxicity was detected in vivo after application of liposomal a-TAM, which significantly reduced the growth of cancer cells in hollow fiber implants. Moreover, liposomal formulation of a-TAM and a-TOS each prevented the growth of tumours in transgenic FVB/N c-neu mice bearing spontaneous breast carcinomas.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology and Applied Pharmacology

ISSN

0041-008X

e-ISSN

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Volume of the periodical

237

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000266689800001

EID of the result in the Scopus database

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