Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000510" target="_blank" >RIV/00027162:_____/09:#0000510 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

Original language description

Salmonella enterica serovars Typhimurium or Enteritidis can colonise liver and spleen in particular hosts while infections with serovars Infantis, Agona, Hadar etc. are usually limited to gastrointestinal tract. Reasons for this behavior are unknown, although it has been shown that sodCI and spv genes exhibit a strict distribution between more and less virulent serovars and they influence Salmonella virulence. In this study we therefore removed these two genes from S. Enteritidis genome and compared thevirulence of such a mutant with the virulence of S. Infantis, S. Agona and S. Hadar for chickens and highly sensitive Balb/C mice. Single strain infections showed that the deletion of these two genes from S. Enteritidis resulted in the reduction of itsvirulence for mice but not for chickens. This indicated that in mice but not in chickens the virulence of sodCI and spv mutant was reduced to the natural virulence of serovars Infantis, Agona and Hadar.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

—

Project

<a href="/en/project/LC06030" target="_blank" >LC06030: Biomolecular centre</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary Microbiology

ISSN

0378-1135

e-ISSN

—

Volume of the periodical

139

Issue of the periodical within the volume

3-4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

—

UT code for WoS article

000271775700013

EID of the result in the Scopus database

—