Antimicrobial and anticancer peptides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000542" target="_blank" >RIV/00027162:_____/09:#0000542 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antimicrobial and anticancer peptides
Original language description
Antimicrobial peptides are gene-coded polypeptides that exist in various species, ranging from bacteria, fungi, amphibians, plants, to animals, including humans. In invertebrates, they are the only host defense molecules, whereas in vertebrates these molecules are the key components of innate immunity and may serve as signal molecules to trigger further adaptive immune response. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Cationic antimicrobial peptides provide new hope in a time when conventional antibiotics have been rapidly losing efficacy in the treatment of infections due to problems associated with resistance. It is extremely encouraging to observe these new compounds move through early preclinical to phase III clinical trials in such areas as infectious diseases, cancer and wound healing.
Czech name
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Czech description
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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