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Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators: Beyond CYP1A Regulation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000810" target="_blank" >RIV/00027162:_____/11:#0000810 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/11:00359385

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators: Beyond CYP1A Regulation

  • Original language description

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which plays a major role in toxic effects of environmental pollutants. It is a pivotal regulator of several xenobiotic-metabolizing enzymes (XMEs), and is now considered to play an important role also in control of cell cycle, apoptosis and cell differentiation. The accumulating evidence suggests that there exists a multiple crosstalk between AhR activation and the signaling pathways activated by inflammatory mediators, suchas nuclear factor-kappa B, a pleiotropic transcription factor controlling the immune/inflammatory responses. In this review, we summarize the current knowledge about the interactions of AhR with inflammatory mediators leading to deregulation of the AhR-dependent XMEs, as well as the evidence pointing to the role of AhR in modulation of inflammatory signals. These include altered expression of proinflammatory cytokines, such as tumor necrosis factor-alpha or interleukin-6, and deregulati

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GAP503%2F11%2F1227" target="_blank" >GAP503/11/1227: Interactions of inflammatory mediators and Ah receptor signaling in toxic effects of polycyclic aromatic hydrocarbons</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CURRENT DRUG METABOLISM

  • ISSN

    1389-2002

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    5

  • Pages from-to

    89-103

  • UT code for WoS article

    000289085500003

  • EID of the result in the Scopus database