Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators: Beyond CYP1A Regulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000810" target="_blank" >RIV/00027162:_____/11:#0000810 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/11:00359385

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators: Beyond CYP1A Regulation

Original language description

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which plays a major role in toxic effects of environmental pollutants. It is a pivotal regulator of several xenobiotic-metabolizing enzymes (XMEs), and is now considered to play an important role also in control of cell cycle, apoptosis and cell differentiation. The accumulating evidence suggests that there exists a multiple crosstalk between AhR activation and the signaling pathways activated by inflammatory mediators, suchas nuclear factor-kappa B, a pleiotropic transcription factor controlling the immune/inflammatory responses. In this review, we summarize the current knowledge about the interactions of AhR with inflammatory mediators leading to deregulation of the AhR-dependent XMEs, as well as the evidence pointing to the role of AhR in modulation of inflammatory signals. These include altered expression of proinflammatory cytokines, such as tumor necrosis factor-alpha or interleukin-6, and deregulati

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/GAP503%2F11%2F1227" target="_blank" >GAP503/11/1227: Interactions of inflammatory mediators and Ah receptor signaling in toxic effects of polycyclic aromatic hydrocarbons</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CURRENT DRUG METABOLISM

ISSN

1389-2002

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

5

Pages from-to

89-103

UT code for WoS article

000289085500003

EID of the result in the Scopus database

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