Environmental Estrogens

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F12%3A%230000848" target="_blank" >RIV/00027162:_____/12:#0000848 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Environmental Estrogens
Original language description
Endocrine disrupting chemicals (drugs, environmental contaminants and dietary constituents) are the compounds that interfere with normal endocrine functions. Xenoestrogens may disrupt estorgenic signaling and function at several steps, whichn include alterations of hormonal biosynthesis, transport, acrtion (via specific receptors) and elimination. Agonistic and antagonistic effects of xenobiotics on estrogen receptors and modulations of estrogen concentrations are reviewed. Case of polychlorinated biphenyls shows the complexity of mechanisms underlying the estrogenic/antiestrogenic activities. Low-molecular weight PCBs are weak estrogens; high-chlorinated PCBs are antiestrogtenic. The dioxin-like PCBs are generally antiestrogenic and their effect include direct repression of receptor-dependent gene expression, inhibition of cell cycle regulators and enhanced metabolism of estrogens.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Metabolism of Drugs and Other Xenobiotics
ISBN
9783527329038
Number of pages of the result
14
Pages from-to
671-684
Number of pages of the book
724
Publisher name
Wiley-VCH Verlag & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany
Place of publication
Weinheim, Germany
UT code for WoS chapter
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