Experimental infection of gnotobiotic piglets with Escherichia coli strains positive for EAST1 and AIDA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230000964" target="_blank" >RIV/00027162:_____/13:#0000964 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.09.011" target="_blank" >http://dx.doi.org/10.1016/j.vetimm.2012.09.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.09.011" target="_blank" >10.1016/j.vetimm.2012.09.011</a>

Result language
angličtina
Original language name
Experimental infection of gnotobiotic piglets with Escherichia coli strains positive for EAST1 and AIDA
Original language description
The virulence factors EAST1 and AIDA are often detected in ETEC/VTEC strains isolated from pigs and their role in diarrhoeal infections is discussed. In order to elucidate the pathogenesis of AIDA, the colonisation patterns of F4 positive and AIDA positive strains were investigated. Two wild-type Escherichia coli strains AIDA/EAST1 and F4/EAST1 isolated from diarrhoeal piglets were used for animal experiment to evaluate the ability of the EAST1 toxin to be involved in induction of diarrhoea. Gnotobioticpiglets were supplemented with normal porcine serum and orally inoculated with the strains. Faecal bacterial shedding of the challenge strains was observed during the experiment. Light microscopy and scanning electron microscopy were used to detect thecolonisation pattern of both challenge strains. Although bacterial isolation demonstrated shedding of the challenge strains until the end of the experiment, diarrhoea did not develop in any piglet. Based on histological examination, pigle
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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