Experimental Electrophysiological and Pressure Responses of Urinary Bladder Detrusor to Lumbar to Sacral Nerve Rerouting - An Animal Study with Negative Results

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000095" target="_blank" >RIV/00027162:_____/16:N0000095 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00092507 RIV/65269705:_____/16:00066127 RIV/00159816:_____/16:00066127

Result on the web

<a href="https://www.karger.com/Article/Pdf/448851" target="_blank" >https://www.karger.com/Article/Pdf/448851</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000448851" target="_blank" >10.1159/000448851</a>

Result language

angličtina

Original language name

Experimental Electrophysiological and Pressure Responses of Urinary Bladder Detrusor to Lumbar to Sacral Nerve Rerouting - An Animal Study with Negative Results

Original language description

To verify the transfer of evoked potentials through anastomosis of an experimentally created micturition reflex arc and to detect said potentials directly on the detrusor and sphincter of rabbit urinary bladder. Methods: During 2013-2015, 17 rabbits were operated upon and measurement followed during reoperation 3-16 months later. Suitable ventral spinal roots were electrophysiologically detected following laminectomy, and a somatic-central nervous system-autonomic micturition reflex arc was created. During reoperation, the ventral root was stimulated above and below the anastomosis, the evoked potentials on the bladder detrusor and sphincter were measured, and intravesical pressure was monitored. Results: With stimulation above the anastomosis, 9 animals (53%) displayed a urinary bladder detrusor response and 7 (41%) a sphincter response. Four rabbits (24%) had elevated intravesical pressure. During the control stimulation below the anastomosis, we detected a detrusor response in 7 animals (41%), a sphincter response in 5 (29%), and elevated pressure in 4 (24%). Neither induction of micturition nor decrease in external sphincter activity occurred. Conclusions: Creation of a somatic-CNS-autonomic reflex arc is technically possible. However reflex activity transferring through the anastomosis is detectable on the detrusor only in some individuals, and is unable to induce a micturition reflex with or without accompanying detrusor-sphincter dyssynergia.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

<a href="/en/project/NT13871" target="_blank" >NT13871: Bladder functioning restoration by somato-CNS-autonomic reflex – experimental study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Urologia Internationalis

ISSN

0042-1138

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

421-428

UT code for WoS article

000389566900009

EID of the result in the Scopus database

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