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Nucleoside inhibitors of Zika virus

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000119" target="_blank" >RIV/00027162:_____/16:N0000119 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/16:00466491 RIV/61388963:_____/16:00466491 RIV/60076658:12310/16:43890958

  • Result on the web

    <a href="http://jid.oxfordjournals.org/content/early/2016/05/26/infdis.jiw226.abstract" target="_blank" >http://jid.oxfordjournals.org/content/early/2016/05/26/infdis.jiw226.abstract</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/infdis/jiw226" target="_blank" >10.1093/infdis/jiw226</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Nucleoside inhibitors of Zika virus

  • Original language description

    There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2′-C- or 2′-O-methyl substituted nucleosides, 2′-C-fluoro-2′-C-methyl substituted nucleosides, 3′-O-methyl substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2′-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Infectious Diseases

  • ISSN

    0022-1899

  • e-ISSN

  • Volume of the periodical

    214

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    707-711

  • UT code for WoS article

    000385346400008

  • EID of the result in the Scopus database