Nucleoside inhibitors of Zika virus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000119" target="_blank" >RIV/00027162:_____/16:N0000119 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/16:00466491 RIV/61388963:_____/16:00466491 RIV/60076658:12310/16:43890958
Result on the web
<a href="http://jid.oxfordjournals.org/content/early/2016/05/26/infdis.jiw226.abstract" target="_blank" >http://jid.oxfordjournals.org/content/early/2016/05/26/infdis.jiw226.abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/infdis/jiw226" target="_blank" >10.1093/infdis/jiw226</a>
Alternative languages
Result language
angličtina
Original language name
Nucleoside inhibitors of Zika virus
Original language description
There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2′-C- or 2′-O-methyl substituted nucleosides, 2′-C-fluoro-2′-C-methyl substituted nucleosides, 3′-O-methyl substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2′-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Infectious Diseases
ISSN
0022-1899
e-ISSN
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Volume of the periodical
214
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
707-711
UT code for WoS article
000385346400008
EID of the result in the Scopus database
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