Polycyclic aromatic hydrocarbons and disruption of steroid signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000268" target="_blank" >RIV/00027162:_____/18:N0000268 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00522202
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2468202018300500" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468202018300500</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cotox.2018.12.003" target="_blank" >10.1016/j.cotox.2018.12.003</a>
Alternative languages
Result language
angličtina
Original language name
Polycyclic aromatic hydrocarbons and disruption of steroid signaling
Original language description
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental pollutants that have been primarily studied as mutagenic and genotoxic compounds. Nevertheless, a number of studies have also indicated that PAHs may, either directly or indirectly, interfere with steroid receptors, in particular, with estrogen signaling. The outcome of interactions of PAHs with steroid receptors may be of relevance both to carcinogenic and endocrine disrupting activities of PAHs. This review discusses current insights into the mechanisms underlying the diversity of effects of PAHs (or their mixtures) on steroid signaling, focusing on the role of crosstalk between estrogen receptors and the aryl hydrocarbon receptor, direct effects of PAHs on estrogen signaling, and on the contribution of metabolism to estrogen-like effects of some PAHs. Finally, we comment the available data on interactions of PAHs with other nuclear receptors that are relevant for signaling of androgen receptor, glucocorticoid receptor, and others.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Opinion in Toxicology
ISSN
2468-2020
e-ISSN
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Volume of the periodical
11-12
Issue of the periodical within the volume
October - December 2018
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
27-34
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85059803793