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Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000002" target="_blank" >RIV/00027162:_____/19:N0000002 - isvavai.cz</a>

  • Alternative codes found

    RIV/62157124:16170/19:43877292

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1090023319300383?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1090023319300383?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.tvjl.2019.03.005" target="_blank" >10.1016/j.tvjl.2019.03.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours

  • Original language description

    Cutaneous mast cell tumours (MCT) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5–8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathological grade (P = 0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P > 0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    The Veterinary Journal

  • ISSN

    1090-0233

  • e-ISSN

    1532-2971

  • Volume of the periodical

    247

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    4

  • Pages from-to

    71-74

  • UT code for WoS article

    000466622700011

  • EID of the result in the Scopus database