Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000002" target="_blank" >RIV/00027162:_____/19:N0000002 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/19:43877292
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1090023319300383?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1090023319300383?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tvjl.2019.03.005" target="_blank" >10.1016/j.tvjl.2019.03.005</a>
Alternative languages
Result language
angličtina
Original language name
Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours
Original language description
Cutaneous mast cell tumours (MCT) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5–8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathological grade (P = 0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P > 0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Veterinary Journal
ISSN
1090-0233
e-ISSN
1532-2971
Volume of the periodical
247
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
71-74
UT code for WoS article
000466622700011
EID of the result in the Scopus database
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