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Lab on a Chip Approach to Develop System Predicting Stenosis Stability

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000287" target="_blank" >RIV/00027162:_____/19:N0000287 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Lab on a Chip Approach to Develop System Predicting Stenosis Stability

  • Original language description

    Thromboembolic diseases like ischemic stroke are leading causes of mortality and morbidity worldwide. Internal carotid stenosis with unstable atherosclerotic plaque is an important condition often leading to the ischemic stroke. Nowadays it is still unclear why some plaques are stable and other unstable creating thromboembolus (thus ischemic stroke). A prediction of plaque stability could help in surgery decision making. We considered the lab on a chip approach with creation of in vitro carotid models with stenosis based on patient’s data. Further, we established physiological flow in the models and studied hemodynamic parameters in healthy parts of carotids and with atherosclerotic plaques. Biochemical surface modifications of models were also considered.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10609 - Biochemical research methods

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů