Regulation of the cell cycle in early mammalian embryos and its clinical implications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000297" target="_blank" >RIV/00027162:_____/19:N0000297 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41598-019-40035-5" target="_blank" >https://www.nature.com/articles/s41598-019-40035-5</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Regulation of the cell cycle in early mammalian embryos and its clinical implications
Original language description
Early embryonic development is characterized by a plethora of very complex and simul¬taneously operating processes, which are constantly changing cellular morphology and behaviour. After fertilization, blastomeres of the newly created embryo undergo global epigenetic changes and simultaneously initiate transcription from the zygotic genome and differentiation forming separate cell lineages. Some of these mechanisms were extensively studied during the last several decades and valuable insight was gained into how these processes are regulated at the molecular level. We have, however, a still very limited understanding of how multiple events are coordinated during rapid development of an early mammalian embryo. In this review, we discuss some aspects of early embryonic development in mammals, namely the fidelity of chromosome segregation and occur¬rence of aneuploidy, as well as the clinical applications of cell cycle monitoring in human embryos.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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