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Characterization of humoral and cell-mediated immunity in rabbits orally infected with Encephalitozoon cuniculi

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000065" target="_blank" >RIV/00027162:_____/20:N0000065 - isvavai.cz</a>

  • Result on the web

    <a href="https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-020-00806-9" target="_blank" >https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-020-00806-9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s13567-020-00806-9" target="_blank" >10.1186/s13567-020-00806-9</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Characterization of humoral and cell-mediated immunity in rabbits orally infected with Encephalitozoon cuniculi

  • Original language description

    Encephalitozoonosis is a common infectious disease widely spread among rabbits.Encephalitozoon cuniculi, is considered as a zoonotic and emerging pathogen capable of infecting both immunocompetent and immunocompromised hosts. The aim of the study was to describe in detail the spread of theE. cuniculiin a rabbit organism after experimental infection and the host humoral and cellular immune response including cytokine production. For that purpose, healthy immunocompetent rabbits were infected orally in order to simulate the natural route of infection and euthanised at 2, 4, 6 and 8-weeks post-infection. Dissemination ofE. cuniculiin the body of the rabbit was more rapid than previously reported. As early as 2 weeks post-infection,E. cuniculiwas detected using immunohistochemistry not only in the intestine, mesenteric lymph nodes, spleen, liver, kidneys, lungs and heart, but also in nervous tissues, especially in medulla oblongata, cerebellum, and leptomeninges. Based on flow cytometry, no conspicuous changes in lymphocyte subpopulations were detected in the examined lymphoid organs of infected rabbits. Cell-mediated immunity was characterized by ability of both CD4(+)and CD8(+)T cells to proliferate after stimulation with specific antigens. Th1 polarization of immune response with a predominance of IFN-gamma expression was detected in spleen, mesenteric lymph nodes and Peyer's patches. The increased expression of IL-4 and IL-10 mRNA in mixed samples from the small intestine is indicative of balanced control of IFN-gamma, which prevents tissue damage. On the other hand, it can enableE. cuniculito survive and persist in the host organism in a balanced host-parasite relationship. The Th17 immunity lineage seems to play only a minor role inE. cuniculiinfection in rabbits.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40301 - Veterinary science

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    VETERINARY RESEARCH

  • ISSN

    0928-4249

  • e-ISSN

    1297-9716

  • Volume of the periodical

    51

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

    "79"

  • UT code for WoS article

    000542952100003

  • EID of the result in the Scopus database

    2-s2.0-85086623341