Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000092" target="_blank" >RIV/00027162:_____/20:N0000092 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/20:00118240
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0168365920303229?dgcid=rss_sd_all" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0168365920303229?dgcid=rss_sd_all</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2020.05.045" target="_blank" >10.1016/j.jconrel.2020.05.045</a>
Alternative languages
Result language
angličtina
Original language name
Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery
Original language description
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great variability in its physical-chemical properties and is a basis for its broad successful application in pharmaceutical research, development, and manufacturing. The excellent mucoadhesive properties of HPMC predetermine its use in oromucosal delivery systems including mucoadhesive tablets and films. HPMC also possesses desirable properties for formulating amorphous solid dispersions increasing the oral bioavailability of poorly soluble drugs. Printability and electrospinnability of HPMC are promising features for its application in 3D printed drug products and nanofiberbased drug delivery systems. Nanoparticle-based formulations are extensively explored as antigen and protein carriers for the formulation of oral vaccines, and oral delivery of biologicals including insulin, respectively. HPMC, being a traditional pharmaceutical excipient, has an irreplaceable role in the development of new pharmaceutical technologies, and new drug products leading to continuous manufacturing processes, and personalized medicine. This review firstly provides information on the physical-chemical properties of HPMC and a comprehensive overview of its application in traditional oral drug formulations. Secondly, this review focuses on the application of HPMC in modern pharmaceutical technologies including spray drying, hot-melt extrusion, 3D printing, nanoprecipitation and electrospinning leading to the formulation of printlets, nanoparticle-, microparticle-, and nanofiber-based delivery systems for oral and oromucosal application.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Pharmacology, Immunotherapy, nanoToxicology)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF CONTROLLED RELEASE
ISSN
0168-3659
e-ISSN
1873-4995
Volume of the periodical
324
Issue of the periodical within the volume
AUG 10 2020
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
33
Pages from-to
695-727
UT code for WoS article
000558614500009
EID of the result in the Scopus database
2-s2.0-85087198703