FDA-Approved Drugs Efavirenz, Tipranavir, and dasabuvir Inhibit Replication of Multiple Flavivures in Vero Cels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000104" target="_blank" >RIV/00027162:_____/20:N0000104 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-2607/8/4/599" target="_blank" >https://www.mdpi.com/2076-2607/8/4/599</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/microorganisms8040599" target="_blank" >10.3390/microorganisms8040599</a>
Alternative languages
Result language
angličtina
Original language name
FDA-Approved Drugs Efavirenz, Tipranavir, and dasabuvir Inhibit Replication of Multiple Flavivures in Vero Cels
Original language description
Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S. Food and Drug Administration-approved antiviral drugs for their interaction with Zika virus proteins. Twelve hit drugs were identified by the docking experiments and tested in cell-based antiviral assay systems. Efavirenz, tipranavir, and dasabuvir at micromolar concentrations were identified to inhibit all VBFs tested; i.e., two representatives of mosquito-borne flaviviruses (Zika and West Nile viruses) and one representative of flaviviruses transmitted by ticks (tick-borne encephalitis virus). The results warrant further research into these drugs, either individually or in combination, as possible pan-flavivirus inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Pharmacology, Immunotherapy, nanoToxicology)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MICROORGANISMS
ISSN
2076-2607
e-ISSN
2076-2607
Volume of the periodical
8
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
"599"
UT code for WoS article
000533510400128
EID of the result in the Scopus database
2-s2.0-85084005221