Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000066" target="_blank" >RIV/00027162:_____/21:N0000066 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16270/21:43879275 RIV/62156489:43210/21:43919911

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fvets.2021.679970/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fvets.2021.679970/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fvets.2021.679970" target="_blank" >10.3389/fvets.2021.679970</a>

Result language

angličtina

Original language name

Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Original language description

Emerging viral diseases associated with significant mortality challenge the economy of common carp aquaculture. It is therefore necessary to disentangle how infected fish cope with progressive disease pathology, losing their ability for homeostatic maintenance of key physiological parameters. Having an opportunity to examine diseased carps and those that stayed healthy in the same storage pond under conditions of natural carp edema virus (CEV) infection outbreak, here we contribute to better understanding of the CEV disease pathophysiology. The disease status of fish was determined using virus identification with polymerase chain reaction combined with gill pathology. Compared with control healthy carps, the blood chemistry profile analysis of CEV-diseased fish revealed major disruption in electrolyte and acid-base balance (i.e. hyponatremia, hypochloremia, hyperphosphatemia, elevated pH, base excess and anion gap, and decreased partial dissolved carbon dioxide), hyperproteinemia, hyperalbuminemia, hypotonic dehydration, endogenous hyperammonemia, decreased lactate and increased creatinine, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. Red blood cell associated haematology variables were also elevated. The multivariate pattern of responses of blood chemistry variables (driven by sodium, pH, partial dissolved carbon dioxide, ammonia and albumin in the principal component analysis) discriminated clearly between CEV-diseased and control carps. To conclude, we show that CEV infection of carps exerts complex adverse effects and results in severe metabolic disturbance due to impaired respiratory and excretory functions of gills

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40103 - Fishery

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Veterinary Science

ISSN

2297-1769

e-ISSN

2297-1769

Volume of the periodical

8

Issue of the periodical within the volume

19 May 2021

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

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UT code for WoS article

000656847800001

EID of the result in the Scopus database

2-s2.0-85107285679