The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000075" target="_blank" >RIV/00027162:_____/21:N0000075 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/21:00560388
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/hsr2.260" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/hsr2.260</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hsr2.260" target="_blank" >10.1002/hsr2.260</a>

Result language
angličtina
Original language name
The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution
Original language description
Impact of age on semen quality was studied in healthy nonsmoking men. Semen samples from 150 Prague City policemen aged 23-63 years were examined for standard semen parameters, sperm DNA fragmentation and high DNA stainability. A significant positive correlation was found between age and %DFI (r = 0.359, p  0.001), and negative correlations were found between age and sperm vitality (r = -0.247, p  0.001), the % acrosome-intact sperm (r = -0.202, p = 0.013) and the % normal sperm heads (r = -0.204, p=0.012). A weak but significant negative correlation was found for high DNA stainability (% HDS) vs. age (r = -0.161, p = 0.050). No significant correlation was detected between male age and the other investigated semen quality parameters. At ages of 23-30, 31-40, 41-50, and 51-63 years, the mean %DFI values were 12.7±7.18, 14.7±7.42, 19.6±11.25, and 34.2±15.08, respectively. Our study shows a strong relationship (p < 0.001) between the age of men and sperm DNA fragmentation in an occupational cohort at risk of exposure to heavy traffic-related air pollution in a large city centre.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)

Project
<a href="/en/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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