Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000108" target="_blank" >RIV/00027162:_____/21:N0000108 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00548797 RIV/62157124:16170/21:43879840
Result on the web
<a href="https://rupress.org/jem/article/218/5/e20210236/211958/Broad-and-potent-neutralizing-human-antibodies-to" target="_blank" >https://rupress.org/jem/article/218/5/e20210236/211958/Broad-and-potent-neutralizing-human-antibodies-to</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1084/jem.20210236" target="_blank" >10.1084/jem.20210236</a>

Result language
angličtina
Original language name
Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease
Original language description
Tick-borne encephalitis virus (TBEV) is an emerging human pathogen that causes potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are protective against TBEV, but little is known about the human antibody response to infection. Here, we report on the human neutralizing antibody response to TBEV in a cohort of infected and vaccinated individuals. Expanded clones of memory B cells expressed closely related anti-envelope domain III (EDIII) antibodies in both groups of volunteers. However, the most potent neutralizing antibodies, with IC50s below 1 ng/ml, were found only in individuals who recovered from natural infection. These antibodies also neutralized other tick-borne flaviviruses, including Langat, louping ill, Omsk hemorrhagic fever, Kyasanur forest disease, and Powassan viruses. Structural analysis revealed a conserved epitope near the lateral ridge of EDIII adjoining the EDI–EDIII hinge region. Prophylactic or early therapeutic antibody administration was effective at low doses in mice that were lethally infected with TBEV.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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