Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000011" target="_blank" >RIV/00027162:_____/22:N0000011 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/22:43921042 RIV/00216224:14160/22:00125799 RIV/62157124:16170/22:43880318 RIV/62157124:16270/22:43880318
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1382668922000114" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668922000114</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2022.103818" target="_blank" >10.1016/j.etap.2022.103818</a>

Result language
angličtina
Original language name
Foodborne fluoxetine impacts the immune response in rainbow trout (Oncorhynchus mykkis)
Original language description
The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, haematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in haematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology

Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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