All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000258" target="_blank" >RIV/00027162:_____/22:N0000258 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration

  • Original language description

    Infectious complications play a crucial role in morbidity and mortality in patients with thermal injury. The compromisation of the local barrier, together with the presence of necrotic tissue and specific immunoparalysis in these patients, causes very rapid propagation of pathogens into the deeper layers and the development of local infection or systemic sepsis. Commonly as in other patients with critical illness, there is a very well documented increasing trend in antimicrobial resistance. The only way how we can manage the increasing resistance of pathogens is to extend the spectrum of available antimicrobials and reduce selective pressure. One of the most promising options is the application of antibacterial enzymes called "enzybiotics" derived from the enzymatic machinery of bacteriophages (endolysins) or competitive bacteria (e.g. lysostaphin). Within in vitro testing, we evaluated 13 different sequence types of methicillin-resistant Staphylococcus aureus strains epidemiologically relevant for burned patients. Most of these tested strains were sensitive to lysostaphin. However, during in vitro testing, we identified a few strains that were sensitive only to higher concentrations of enzymes.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    30303 - Infectious Diseases

Result continuities

  • Project

    <a href="/en/project/NV19-05-00214" target="_blank" >NV19-05-00214: Study of therapeutic application of antibacterial wound dressing for skin and soft tissue infections in epidemiologically relevant strains of S. aureus - methicillin resistant.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů