Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F22%3AN0000258" target="_blank" >RIV/00027162:_____/22:N0000258 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Staphylococcus aureus Burn Wound Infection: treatment perspectives with enzybiotics in topical administration
Original language description
Infectious complications play a crucial role in morbidity and mortality in patients with thermal injury. The compromisation of the local barrier, together with the presence of necrotic tissue and specific immunoparalysis in these patients, causes very rapid propagation of pathogens into the deeper layers and the development of local infection or systemic sepsis. Commonly as in other patients with critical illness, there is a very well documented increasing trend in antimicrobial resistance. The only way how we can manage the increasing resistance of pathogens is to extend the spectrum of available antimicrobials and reduce selective pressure. One of the most promising options is the application of antibacterial enzymes called "enzybiotics" derived from the enzymatic machinery of bacteriophages (endolysins) or competitive bacteria (e.g. lysostaphin). Within in vitro testing, we evaluated 13 different sequence types of methicillin-resistant Staphylococcus aureus strains epidemiologically relevant for burned patients. Most of these tested strains were sensitive to lysostaphin. However, during in vitro testing, we identified a few strains that were sensitive only to higher concentrations of enzymes.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/NV19-05-00214" target="_blank" >NV19-05-00214: Study of therapeutic application of antibacterial wound dressing for skin and soft tissue infections in epidemiologically relevant strains of S. aureus - methicillin resistant.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů